期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.645810
关键词
metformin; bibliometrics analysis; development process; research frontier; Web of Science
资金
- National Natural Science Foundation of China [81573576]
- CAMS Innovation Fund for Medical Sciences [CIFMS 2016-I2M-1-012]
- Fundamental Research Funds for the Central Universities [3332020102]
The study comprehensively analyzed the research status and development history of metformin through bibliometrics and data visualization, and proposed future research directions.
Metformin, the first-line oral blood glucose-lowering agent to manage type 2 diabetes, has gained growing popularity on both clinical application and basic research since early 1980s. A thorough and systematic knowledge map of metformin is pertinent to evaluate the research frontier and determine knowledge gaps. To this end, 20, 526 publications were analyzed by bibliometrics and data visualization to demonstrate the current global research status, potential hotspots, and perspectives on future research directions. In addition, the metformin development along the historical line was illustrated over the last 40 years. In sum, this study provides a comprehensive analysis that delineates the evolution of the historical milestones of metformin development, and we discuss the future research directions based on objective data analysis from a wide spectrum of metformin research areas.
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