4.7 Article

Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Plant Sciences

Identification of potential bioactive compounds and mechanisms of GegenQinlian decoction on improving insulin resistance in adipose, liver, and muscle tissue by integrating system pharmacology and bioinformatics analysis

Zebiao Cao et al.

Summary: Our study identifies potential bioactive compounds, targets, and pathways of GQD in improving IR in T2DM for adipose, liver, and muscle tissue, showing the characteristics of multi-compounds, multi-targets, multi-pathways, and multi-mechanisms of GQD. This lays a solid foundation for further experimental research and clinical application.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

Jargalsaikhan Dagvadorj et al.

Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Biochemistry & Molecular Biology

Mitochondrial reactive zones in antiviral innate immunity

Kai Yasukawa et al.

Summary: Mitochondria are multi-functioning organelles involved in a wide range of biological processes and innate immune responses against microorganisms or irritants. Activation of two signaling pathways, NLR family pyrin domain-containing 3 inflammasomes and retinoic acid-inducible gene I-like receptor pathway, is crucial for mitochondrial-mediated innate immunity. Targeting mitochondrial functions could be a potential therapeutic approach for managing infectious diseases and autoinflammatory disorders.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Article Biochemistry & Molecular Biology

Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells

Zhao-Ming Yu et al.

Summary: The study found that puerarin can prevent autophagy inhibition and NLRP3 inflammasome activation induced by cadmium by restoring Nrf2 pathway, providing novel insights into the protection of puerarin against cadmium-induced hepatic cell damage.

JOURNAL OF INORGANIC BIOCHEMISTRY (2021)

Article Integrative & Complementary Medicine

Deciphering the Molecular Targets and Mechanisms of HGWD in the Treatment of Rheumatoid Arthritis via Network Pharmacology and Molecular Docking

Wei Liu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Article Integrative & Complementary Medicine

Network Pharmacology Identifies the Mechanisms of Sang-Xing-Zhi-Ke-Fang against Pharyngitis

Yinhe Deng et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Article Endocrinology & Metabolism

TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease

Youliang Wang et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Article Medicine, Research & Experimental

Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice

Yihan Wu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Biochemistry & Molecular Biology

Bax, Bak and beyond - mitochondrial performance in apoptosis

Aida Pena-Blanco et al.

FEBS JOURNAL (2018)

Article Transplantation

Uric acid predicts adverse outcomes in chronic kidney disease: a novel insight from trajectory analyses

Ching-Wei Tsai et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)

Article Urology & Nephrology

Uric Acid and the Risks of Kidney Failure and Death in Individuals With CKD

Anand Srivastava et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2018)

Article Biochemistry & Molecular Biology

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

Yubin Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Impaired Na+ - K+-ATPase signaling in renal proximal tubule contributes to hyperuricemia-induced renal tubular injury

Jing Xiao et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Article Endocrinology & Metabolism

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

Zhenjiang Liu et al.

JOURNAL OF PINEAL RESEARCH (2017)

Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Jianjin Shi et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Review Biochemistry & Molecular Biology

Nrf2 signaling pathway: Pivotal roles in inflammation

Syed Minhaj Uddin Ahmed et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Biochemistry & Molecular Biology

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Lorenzo Sborgi et al.

EMBO JOURNAL (2016)

Article Integrative & Complementary Medicine

The Efficacy and Safety of Chinese Herbal Decoction in Type 2 Diabetes: A 5-Year Retrospective Study

Jiaxing Tian et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Review Chemistry, Medicinal

Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents

Spandana Rajendra Kopalli et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

Article Multidisciplinary Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding et al.

NATURE (2016)

Review Pharmacology & Pharmacy

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome

Nader G. Abraham et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

ASSOCIATION OF BAX EXPRESSION AND BCL2/BAX RATIO WITH CLINICAL AND MOLECULAR PROGNOSTIC MARKERS IN CHRONIC LYMPHOCYTIC LEUKEMIA

Ksenija Vucicevic et al.

JOURNAL OF MEDICAL BIOCHEMISTRY (2016)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

V. Derangere et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Genetics & Heredity

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

Alexander Wree et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

Article Medicine, General & Internal

Prevalence and Control of Diabetes in Chinese Adults

Yu Xu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

Article Rheumatology

Regulation of Uric Acid Excretion by the Kidney

Michael S. Lipkowitz

CURRENT RHEUMATOLOGY REPORTS (2012)

Article Medical Laboratory Technology

Oligomycin and antimycin A prevent nitric oxide-induced opoptosis by blocking cytochrome C leakage

N Dairaku et al.

JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2004)