期刊
FRONTIERS IN NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.649459
关键词
neurostimulation; neuromodulation; stroke; closed-loop stimulation; optogenetic stimulation; brain-computer interfaces; neural plasticity
资金
- Fonds de recherche du QuebecSante (FRQS)
- Canada Research Chair in Cognitive Neuroplasticity
- FRQS [35012]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2017-06120]
- Fonds de recherche du Quebec-Nature et technologies [2021-PR-284207]
Neurological injuries such as strokes can result in loss of motor function, but neuronal plasticity allows for potential recovery over time. Neuromodulation interventions are being developed to harness neural plasticity for faster and more complete recovery after such injuries.
Neurological injuries such as strokes can lead to important loss in motor function. Thanks to neuronal plasticity, some of the lost functionality may be recovered over time. However, the recovery process is often slow and incomplete, despite the most effective conventional rehabilitation therapies. As we improve our understanding of the rules governing activity-dependent plasticity, neuromodulation interventions are being developed to harness neural plasticity to achieve faster and more complete recovery. Here, we review the principles underlying stimulation-driven plasticity as well as the most commonly used stimulation techniques and approaches. We argue that increased spatiotemporal precision is an important factor to improve the efficacy of neurostimulation and drive a more useful neuronal reorganization. Consequently, closed-loop systems and optogenetic stimulation hold theoretical promise as interventions to promote brain repair after stroke.
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