期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.597812
关键词
parvalbumin; perineuronal net; autism spectrum disorder; valproic acid; chondroitinase ABC
资金
- National Nature Science Foundation of China [82003555]
- China Postdoctoral Science Foundation [2020M672744, 2020TQ0135]
- [2019SHIBS0004]
- [SZBL2019062801003]
- [KQTD2015032709315529]
- [SZSM201612036]
Altered function of inhibitory neurons, particularly the PV-containing neurons with reduced density and intensity, is observed in ASD patients and model mice. The relationship between PV and PNN intensities is disrupted in VPA mice, which can be corrected by reducing PNN levels, indicating a potential contribution to the pathology of ASD.
Altered function or presence of inhibitory neurons is documented in autism spectrum disorders (ASD), but the mechanism underlying this alternation is poorly understood. One major subtype of inhibitory neurons altered is the parvalbumin (PV)-containing neurons with reduced density and intensity in ASD patients and model mice. A subpopulation of PV+ neurons expresses perineuronal nets (PNN). To better understand whether the relationship between PV and PNN is altered in ASD, we measured quantitatively the intensities of PV and PNN in single PV+ neurons in the prelimbic prefrontal cortex (PrL-PFC) of a valproic acid (VPA) model of ASD at different ages. We found a decreased PV intensity but increased PNN intensity in VPA mice. The relationship between PV and PNN intensities is altered in VPA mice, likely due to an abnormal subpopulation of neurons with an altered PV-PNN relationship. Furthermore, reducing PNN level using in vivo injection of chondroitinase ABC corrects the PV expression in adult VPA mice. We suggest that the interaction between PV and PNN is disrupted in PV+ neurons in VPA mice which may contribute to the pathology in ASD.
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