期刊
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
卷 48, 期 4, 页码 292-298出版社
ASSOC BRAS DIVULG CIENTIFICA
DOI: 10.1590/1414-431X20144310
关键词
Molecular mechanism; Pathogenesis; Programmed cell death; Therapy
资金
- National Natural Science Foundation of China [81070988, 81171166]
- Science and Technology Committee of Shanghai [0852nm04900, 11nm0503200, 11JC1408602]
- National Natural Science Foundation of China [81070988, 81171166]
- Science and Technology Committee of Shanghai [0852nm04900, 11nm0503200, 11JC1408602]
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据