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Affinity Sensors for the Diagnosis of COVID-19

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Summary: Researchers have identified potential G-quadruplex-forming sequences in the SARS-CoV-2 RNA genome and other Coronaviridae family members, with some confirmed to form RNA G-quadruplex structures in vitro. These structures were found to interact with viral helicase (nsp13), suggesting a potential target for inhibiting the virus.

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Summary: In this study, a pencil graphite electrode was used for the electrochemical synthesis of polypyrrole in aqueous solutions with different pH values. The research found that polypyrrole synthesized at low pH exhibited better longevity. Additionally, it was observed that the degradation of the Ppy layer was faster when stored in a phosphate buffer solution, possibly due to oxygen dissolved in the aqueous medium.

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Development of a reverse transcription recombinase polymerase amplification assay for rapid and direct visual detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

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PLOS ONE (2021)

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Ultrasensitive supersandwich-type electrochemical sensor for SARS-CoV-2 from the infected COVID-19 patients using a smartphone

Hui Zhao et al.

Summary: The study developed an ultrasensitive electrochemical detection technology using calixarene functionalized graphene oxide for targeting SARS-CoV-2 RNA without the need for nucleic acid amplification and reverse transcription. The biosensor demonstrated high specificity and selectivity, offering a rapid and convenient method for SARS-CoV-2 detection at the point of care.

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Conducting Polymers in the Design of Biosensors and Biofuel Cells

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Summary: This review highlights the importance of conducting polymers in sensors and biosensors design, focusing on the most frequently used CPs and their applications in various industries. It also discusses popular polymerization methods and signal transduction mechanisms in CP-based sensors. Future trends and perspectives in sensor development based on CPs and their composites are also explored.

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The application of DNA polymerases and Cas9 as representative of DNA-modifying enzymes group in DNA sensor design (review)

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Summary: During the pandemic, various methods for SARS-CoV-2 detection and COVID-19 diagnostics were developed, which included antibody and antigen tests. Recent research has shown that the interaction between SCoV2-rN and anti-SCoV2-rN antibodies plays a crucial role in guiding the development of new medications.

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Simonas Ramanavicius et al.

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Daniel Wrapp et al.

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Antibody Detection and Dynamic Characteristics in Patients With Coronavirus Disease 2019

Fei Xiang et al.

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Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity

Weilie Chen et al.

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Xiaowei Li et al.

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Nicole D. Pecora et al.

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Evaluations of the serological test in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak

Dachuan Lin et al.

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Evaluation of a novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples

Lorena Porte et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Types of Assays for SARS-CoV-2 Testing: A Review

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LABORATORY MEDICINE (2020)

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Diagnostic methods and potential portable biosensors for coronavirus disease 2019

Feiyun Cui et al.

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COVID-19: molecular and serological detection methods

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Antibody response to SARS-CoV-2 infection in humans: A systematic review

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PLOS ONE (2020)

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G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection

Hui Xi et al.

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Jochen Spiegel et al.

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Plasmonic-based platforms for diagnosis of infectious diseases at the point-of-care

Zihan Li et al.

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Photoluminescence immunosensor based on bovine leukemia virus proteins immobilized on the ZnO nanorods

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EDTA-modified PANI/SWNTs nanocomposite for differential pulse voltammetry based determination of Cu(II) ions

Megha A. Deshmukh et al.

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A computational approach to study functional monomer-protein molecular interactions to optimize protein molecular imprinting

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NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

Andrew S. Dixon et al.

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Pre-fusion structure of a human coronavirus spike protein

Robert N. Kirchdoerfer et al.

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Plasmon-enhanced optical sensors: a review

Ming Li et al.

ANALYST (2015)

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Coronavirus envelope (E) protein remains at the site of assembly

Pavithra Venkatagopalan et al.

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Molecularly Imprinted Polypyrrole Based Impedimentric Sensor for Theophylline Determination

Vilma Ratautaite et al.

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Article Chemistry, Analytical

Electrochemical deposition of gold nanoparticles on graphite rod for glucose biosensing

Natalija German et al.

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Electrochemical formation of polypyrrole-based layer for immunosensor design

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Self-assembled magnetoplasmonic nanochain for DNA sensing

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Surface plasmon resonance sensing of nucleic acids: A review

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Surface molecularly imprinted polydopamine films for recognition of immunoglobulin G

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Evaluation of intact- and fragmented-antibody based immunosensors by total internal reflection ellipsometry

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Capacitive micromachined ultrasound transducer (cMUT) for immunosensor design

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Electrosynthesized Surface-Imprinted Conducting Polymer Microrods for Selective Protein Recognition

Anna Menaker et al.

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