期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-021-00862-z
关键词
Persistent luminescence nanoparticles; Synthesis; Surface modification; PersL imaging; Multiple excitation sources; Theranostics
资金
- National Natural Science Foundation of China [61705228, 81971738, 81571743]
- National Key Research and Development Program of China [2016YFA0203600]
- Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University [SKLNMZZRC05]
PLNPs are unique optical materials that emit afterglow luminescence after ceasing excitation, making them ideal for in vivo optical imaging of tumors. They have advantages such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources. Furthermore, they are widely used in cancer theranostics applications, including fluorescence-guided surgery, photothermal therapy, photodynamic therapy, drug/gene delivery, and combined therapy.
Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLNPs are also widely used in persistent luminescence (PersL) imaging-guided tumor therapy. In this review, we first summarize the recent developments in the synthesis and surface functionalization of PLNPs, as well as their toxicity studies. We then discuss the in vivo PersL imaging and multimodal imaging from different excitation sources. Furthermore, we highlight PLNPs-based cancer theranostics applications, such as fluorescence-guided surgery, photothermal therapy, photodynamic therapy, drug/gene delivery and combined therapy. Finally, future prospects and challenges of PLNPs in the research of translational medicine are also discussed.
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