4.7 Article

Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE-/- mice

期刊

JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12951-021-00863-y

关键词

Nanomedicine; Atherosclerosis; Macrophages; Phagocytosis; Foam cell

资金

  1. National Natural Science Foundation of China [12032007, 31971242]
  2. Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0307, cstc2019jcyj-19zdxmX0009, cstc2019jcyjzdxmX0028]
  3. Fundamental Research Funds for the Central Universities [2019CDYGZD002, 2020CDCGJ011]

向作者/读者索取更多资源

The study investigated the effects of PLGA NPs on the development of aortic atherosclerotic plaques in ApoE(-/-) mice, showing that the accumulation of PLGA NPs significantly increased plaque extension, expression of inflammatory factors, and accelerated macrophage conversion to foam cells. These results highlight the importance of understanding the interaction between PLGA NPs and atherosclerotic plaques for future nanomaterial design and use in cardiovascular disease treatment.
The unique physiochemical properties of nanomaterials have been widely used in drug delivery systems and diagnostic contrast agents. The safety issues of biomaterials with exceptional biocompatibility and hemo-compatibility have also received extensive attention at the nanoscale, especially in cardiovascular disease. Therefore, we conducted a study of the effects of poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) on the development of aortic atherosclerotic plaques in ApoE(-/-) mice. The particle size of PLGA NPs was 92.69 +/- 3.1 nm and the zeta potential were - 31.6 +/- 2.8 mV, with good blood compatibility. ApoE(-/-) mice were continuously injected with PLGA NPs intravenously for 4 and 12 weeks. Examination of oil red O stained aortic sinuses confirmed that the accumulation of PLGA NPs caused a significantly higher extension of atherosclerotic plaques and increasing the expression of associated inflammatory factors, such as TNF-alpha and IL-6. The combined exposure of ox-LDL and PLGA NPs accelerated the conversion of macrophages to foam cells. Our results highlight further understanding the interaction between PLGA NPs and the atherosclerotic plaques, which we should consider in future nanomaterial design and pay more attention to the process of using nano-medicines on cardiovascular diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据