期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.685670
关键词
bacterial epigenetics; DNA methylation; methylome; transcriptome; phenotypic heterogeneity
类别
资金
- European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant [801505]
- GAIA doctoral school [584]
- INRA Plant Health and Environment (SPE) division [SPE-IB17-DiscriMet]
- French National Research Agency (EPI-PATH project) [ANR-17-CE20-0005]
This article discusses the role of DNA methylation in bacterial phenotypic heterogeneity, mentioning the use of powerful sequencing tools and the future emphasis on the use of methylomic data.
DNA methylation can be part of epigenetic mechanisms, leading to cellular subpopulations with heterogeneous phenotypes. While prokaryotic phenotypic heterogeneity is of critical importance for a successful infection by several major pathogens, the exact mechanisms involved in this phenomenon remain unknown in many cases. Powerful sequencing tools have been developed to allow the detection of the DNA methylated bases at the genome level, and they have recently been extensively applied on numerous bacterial species. Some of these tools are increasingly used for metagenomics analysis but only a limited amount of the available methylomic data is currently being exploited. Because newly developed tools now allow the detection of subpopulations differing in their genome methylation patterns, it is time to emphasize future strategies based on a more extensive use of methylomic data. This will ultimately help to discover new epigenetic gene regulations involved in bacterial phenotypic heterogeneity, including during host-pathogen interactions.
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