期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.657036
关键词
circular RNA; circRNA; oncogenic virus; EBV; KSHV; HPV; MCV; HBV
类别
资金
- National Cancer Institute of the National Institutes of Health [R01CA261258]
- National Institutes of Health COBRE grant [P20GM121288]
- CRDF Global [DAA3-19-65602-1]
- Tulane school of medicine faculty research pilot grant
- Carol Lavin Bernick faculty grant
- Japan Society for the Promotion of Science [JP17K4567]
- Takeda Science Foundation
- Shiseido Female Researcher Science Grant
- U.S.-Japan Cooperative Medical Sciences Program Collaborative Award from the National Institute of Allergy and Infectious Diseases
The review discusses the roles of circular RNAs (circRNAs) in human oncogenic viruses, highlighting their importance in viral infection cycles and virus-associated pathogenesis. The study also explores the recent advancements in identifying novel virally-encoded circRNAs (vcircRNAs) and the potential implications for further research in this field.
Human oncogenic viruses are a group of important pathogens that etiologically contribute to at least 12% of total cancer cases in the world. As an emerging class of non-linear regulatory RNA molecules, circular RNAs (circRNAs) have gained increasing attention as a crucial player in the regulation of signaling pathways involved in viral infection and oncogenesis. With the assistance of current circRNA enrichment and detection technologies, numerous novel virally-encoded circRNAs (vcircRNAs) have been identified in the human oncogenic viruses, initiating an exciting new era of vcircRNA research. In this review, we discuss the current understanding of the roles of vcircRNAs in the respective viral infection cycles and in virus-associated pathogenesis.
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