期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.621156
关键词
KSHV; energy metabolism; viral reprogramming; oncogenesis; herpesvirus
资金
- National Natural Science Foundation of China [81971930, 81772166]
- National Key Research and Development Program of China [2019ZX09721001]
- Research Program on Biosafety Guarantee Technology of High-level Biosafety Laboratory [2018ZX10734401-004]
- Research Program on Biosafety Guarantee Technology of Important Pathogen Laboratory [2018ZX10734401-004]
This review summarizes recent studies on how KSHV manipulates host cell metabolism to promote viral pathogenesis, providing potential therapeutic targets and strategies for KSHV-associated cancers.
Reprogramming of energy metabolism is a key for cancer development. Kaposi's sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. Increasing evidence has shown that KSHV infection can alter central carbon metabolic pathways to produce biomass for viral replication, as well as the survival and proliferation of infected cells. In this review, we summarize recent studies exploring how KSHV manipulates host cell metabolism to promote viral pathogenesis, which provides the potential therapeutic targets and strategies for KSHV-associated cancers.
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