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Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.684515

关键词

drug repurposing; antibiotics; drug development; translational science; reverse translation

资金

  1. NIH Clinical and Translational Science Award (National Center for Advancing Translational Sciences) [UL1 TR002645]

向作者/读者索取更多资源

Drug repurposing is an alternative method to traditional drug discovery processes, utilizing the potential of existing drugs to improve drug development efficiency.
Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative to traditional drug discovery processes involving de novo synthesis. Drugs that are currently approved or under development for non-antibiotic indications may possess antibiotic properties, and therefore may have repurposing potential, either alone or in combination with an antibiotic. They might also serve as antibiotic adjuvants to enhance the activity of certain antibiotics.

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