期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.617573
关键词
Streptococcus pneumoniae; invasive pneumococcal disease; serotype; pneumococcal surface protein A clade; vaccine; Japan; adults
资金
- Ministry of Health and Labour Sciences HA Program [JPMH20HA1005]
- Japan Society for the Promotion of Science KAKENHI [19H03705]
- Japan Agency for Medical Research and Development (AMED) [JP20fk0108139j1901]
- Grants-in-Aid for Scientific Research [19H03705] Funding Source: KAKEN
This study investigated the distribution of PspA clades in causative strains of adult invasive pneumococcal disease (IPD) in Japan, finding that the majority of strains expressed PspA clades 1-4. The distribution of PspA clades varied depending on serotypes and sequence types of pneumococcal strains.
Pneumococcal surface protein A (PspA) is a surface protein of Streptococcus pneumoniae that may be a candidate antigen for new pneumococcal vaccines. This study investigates the distribution of PspA clades of the causative strains of adult invasive pneumococcal disease (IPD) in Japan. Of the 1,939 strains isolated from cases of adult IPD during 2014-2019, the PspA clades of 1,932 (99.6%) strains were determined, and no pspA was detected in the remaining 7 strains (0.4%). PspA clades 1-6 were detected in 786 (40.5%), 291 (15.0%), 443 (22.8%), 369 (19.0%), 33 (1.7%), and 6 (0.3%) strains, respectively. New PspA clades (0.2%) were identified in two non-typeable and two serotype 35B pneumococci. The proportions of Glade 1 and Glade 2 showed significantly decreased and increased trends, respectively. Furthermore, the PspA Glade of pneumococcal strains was partially serotype- and sequence type-dependent. The majority of strains belonging to serotypes contained in both the 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) belonged to PspA clades 1 or 3. In contrast, the distribution of clades in non- vaccine serotypes was wider than that of vaccine serotype pneumococci. Our findings demonstrate that almost all pneumococcal strains from adult IPD express PspA clades 14, especially for non-vaccine serotypes. These results may be useful for the development of a new pneumococcal vaccine with PspA.
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