4.8 Article

Cell-scale biophysical determinants of cell competition in epithelia

期刊

ELIFE
卷 10, 期 -, 页码 -

出版社

ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.61011

关键词

-

类别

资金

  1. Engineering and Physical Sciences Research Council (EPSRC)
  2. Royal Society [URF/R1/180187]
  3. BBSRC [BB/S009329/1]
  4. BBSRC [BB/S009329/1] Funding Source: UKRI

向作者/读者索取更多资源

Studies have shown that cell competition can be driven by short-range biochemical signalling or long-range mechanical stresses in the tissue. In mechanical competition, the key determinant is the difference in homeostatic density between winners and losers, while in biochemical competition, the outcome and kinetics are strongly influenced by local tissue organisation.
How cells with different genetic makeups compete in tissues is an outstanding question in developmental biology and cancer research. Studies in recent years have revealed that cell competition can either be driven by short-range biochemical signalling or by long-range mechanical stresses in the tissue. To date, cell competition has generally been characterised at the population scale, leaving the single-cell-level mechanisms of competition elusive. Here, we use high time-resolution experimental data to construct a multi-scale agent-based model for epithelial cell competition and use it to gain a conceptual understanding of the cellular factors that governs competition in cell populations within tissues. We find that a key determinant of mechanical competition is the difference in homeostatic density between winners and losers, while differences in growth rates and tissue organisation do not affect competition end result. In contrast, the outcome and kinetics of biochemical competition is strongly influenced by local tissue organisation. Indeed, when loser cells are homogenously mixed with winners at the onset of competition, they are eradicated; however, when they are spatially separated, winner and loser cells coexist for long times. These findings suggest distinct biophysical origins for mechanical and biochemical modes of cell competition.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据