期刊
ELIFE
卷 10, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.64694
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资金
- National Research Foundation of Korea [NRF2020R1A6A3A03037088]
- Fonds de la Recherche du Quebec -Sante
- Montreal Neurological Institute and Hospital (MNI)
- British Academy
- Autism Research Trust
- Canadian Institutes of Health Research
- National Institute for Health Research
- Natural Sciences and Engineering Research Council of Canada [1304413]
- Canadian Institutes of Health Research [FDN-154298]
- SickKids Foundation [NI17-039]
- Azrieli Center for Autism Research ACAR-TACC
- Brain Canada
- MNI-Cambridge collaborative award
This study found a marked expansion of structural connectomes during adolescence, with the strongest effects in transmodal regions. The results reflected increased within-module connectivity along with increased segregation, indicating the increasing differentiation of higher-order association networks from the rest of the brain.
Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in a large longitudinal sample ranging from childhood to young adulthood. By projecting high-dimensional connectomes into compact manifold spaces, we identified a marked expansion of structural connectomes, with strongest effects in transmodal regions during adolescence. Findings reflected increased within-module connectivity together with increased segregation, indicating increasing differentiation of higher-order association networks from the rest of the brain. Projection of subcortico-cortical connectivity patterns into these manifolds showed parallel alterations in pathways centered on the caudate and thalamus. Connectome findings were contextualized via spatial transcriptome association analysis, highlighting genes enriched in cortex, thalamus, and striatum. Statistical learning of cortical and subcortical manifold features at baseline and their maturational change predicted measures of intelligence at follow-up. Our findings demonstrate that connectome manifold learning can bridge the conceptual and empirical gaps between macroscale network reconfigurations, microscale processes, and cognitive outcomes in adolescent development.
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