相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Psychosis and longitudinal outcomes in Huntington disease: the COHORT Study
Michael H. Connors et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
Nicholas S. Caron et al.
NUCLEIC ACIDS RESEARCH (2020)
Single-nucleus RNA-seq identifies Huntington disease astrocyte states
Osama Al-Dalahmah et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration
Samir Abu-Rumeileh et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)
Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses
Kirby M. Donnelly et al.
ELIFE (2020)
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Omer Ali Bayraktar et al.
NATURE NEUROSCIENCE (2020)
Abnormal development of cerebellar-striatal circuitry in Huntington disease
Alexander Tereshchenko et al.
NEUROLOGY (2020)
Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms
Hyung-lok Chung et al.
NEURON (2020)
Huntingtin-lowering strategies for Huntington's disease
Roger A. Barker et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)
Huntington's disease alters human neurodevelopment
Monia Barnat et al.
SCIENCE (2020)
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
Lindsey D. Goodman et al.
NATURE NEUROSCIENCE (2019)
Targeting Huntingtin Expression in Patients with Huntington's Disease
Sarah J. Tabrizi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease
Costanza Ferrari Bardile et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Glial Ca2+ signaling links endocytosis to K+ bufferin around neuronal somas to regulate excitability
Shirley Weiss et al.
ELIFE (2019)
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo
Abby L. Olsen et al.
GLIA (2019)
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support
Veronica J. Garcia et al.
FRONTIERS IN NEUROSCIENCE (2019)
Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds
Zhaoyang Li et al.
NATURE (2019)
Astrocyte molecular signatures in Huntington's disease
Blanca Diaz-Castro et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
Mikhail Osipovitch et al.
CELL STEM CELL (2019)
Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model
Tara E. Wood et al.
HUMAN MOLECULAR GENETICS (2019)
Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression
Nuria Cabezas-Llobet et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)
PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1
Vitaliy V. Bondar et al.
HUMAN MOLECULAR GENETICS (2018)
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
Fabia Filipello et al.
IMMUNITY (2018)
An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales
J. Christopher Octeau et al.
NEURON (2018)
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau
Joseph McInnes et al.
NEURON (2018)
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
Iryna Prots et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models
Yeliz Yuva-Aydemir et al.
TRENDS IN NEUROSCIENCES (2018)
High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration
Ismael Al-Ramahi et al.
CELL SYSTEMS (2018)
A Druggable Genome Screen Identifies Modifiers of alpha-Synuclein Levels via a Tiered Cross-Species Validation Approach
Maxime W. C. Rousseaux et al.
JOURNAL OF NEUROSCIENCE (2018)
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease
Alexandra Litvinchuk et al.
NEURON (2018)
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
Farah H. Bardai et al.
PLOS BIOLOGY (2018)
Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Simona Federica Spampinato et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
A Genetic Study of Psychosis in Huntington's Disease: Evidence for the Involvement of Glutamate Signaling Pathways
Debby W. Tsuang et al.
JOURNAL OF HUNTINGTONS DISEASE (2018)
Neurexin gene family variants as risk factors for autism spectrum disorder
Jia Wang et al.
AUTISM RESEARCH (2018)
Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes
Lara Buscemi et al.
CEREBRAL CORTEX (2017)
Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse
Judith A. Blake et al.
NUCLEIC ACIDS RESEARCH (2017)
Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway
Katarina Trajkovic et al.
JOURNAL OF NEUROSCIENCE (2017)
Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis
Jeff A. Stogsdill et al.
NATURE (2017)
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow et al.
NATURE (2017)
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease
Jenny-Ann Phan et al.
SCIENTIFIC REPORTS (2017)
Functional significance of rare neuroligin 1 variants found in autism
Moe Nakanishi et al.
PLOS GENETICS (2017)
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients
Andreas Neueder et al.
SCIENTIFIC REPORTS (2017)
Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
Martha S. Windrem et al.
CELL STEM CELL (2017)
Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP
Yan Hong et al.
JOURNAL OF NEUROSCIENCE (2016)
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice
Ruotian Jiang et al.
JOURNAL OF NEUROSCIENCE (2016)
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice
Peter Langfelder et al.
NATURE NEUROSCIENCE (2016)
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
Abdellatif Benraiss et al.
NATURE COMMUNICATIONS (2016)
Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes
Brenda Huang et al.
NEURON (2015)
NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease
Hong Lian et al.
NEURON (2015)
A survey of human brain transcriptome diversity at the single cell level
Spyros Darmanis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Drosophila Central Nervous System Glia
Marc R. Freeman
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain
Margaret M. P. Pearce et al.
NATURE COMMUNICATIONS (2015)
A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
Yuwei Yao et al.
ELIFE (2015)
Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells
Karen L. Ring et al.
STEM CELL REPORTS (2015)
STRING v10: protein-protein interaction networks, integrated over the tree of life
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2015)
Suppression of agrin-22 production and synaptic dysfunction in Cln1-/- mice
Shiyong Peng et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)
Improving reliability and absolute quantification of human brain microarray data by filtering and scaling probes using RNA-Seq
Jeremy A. Miller et al.
BMC GENOMICS (2014)
Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits
Spencer U. McKinstry et al.
JOURNAL OF NEUROSCIENCE (2014)
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease
Nan Wang et al.
NATURE MEDICINE (2014)
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice
Xiaoping Tong et al.
NATURE NEUROSCIENCE (2014)
Potential function for the Huntingtin protein as a scaffold for selective autophagy
Joseph Ochaba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
GENOME BIOLOGY (2014)
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
Kirupa Sathasivam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
Jacqueline Gire O'Rourke et al.
CELL REPORTS (2013)
Rare Deletions at the Neurexin 3 Locus in Autism Spectrum Disorder
Andrea K. Vaags et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Fast gapped-read alignment with Bowtie 2
Ben Langmead et al.
NATURE METHODS (2012)
Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy
Jennifer S. Ziegenfuss et al.
NATURE NEUROSCIENCE (2012)
An integrative approach to ortholog prediction for disease-focused and other functional studies
Yanhui Hu et al.
BMC BIOINFORMATICS (2011)
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Bo Li et al.
BMC BIOINFORMATICS (2011)
The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
Maria Filimonenko et al.
MOLECULAR CELL (2010)
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
Jennifer Bradford et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Molecular dissection of reactive astrogliosis and glial scar formation
Michael V. Sofroniew
TRENDS IN NEUROSCIENCES (2009)
Excitotoxic neuronal death and the pathogenesis of Huntington's disease
Ana Maria Estrada Sanchez et al.
ARCHIVES OF MEDICAL RESEARCH (2008)
Neuroligins and neurexins link synaptic function to cognitive disease
Thomas C. Sudhof
NATURE (2008)
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
Eliana Romero et al.
NEURON (2008)
Maps of random walks on complex networks reveal community structure
Martin Rosvall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases
Joana Branco et al.
HUMAN MOLECULAR GENETICS (2008)
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Georg Dietzl et al.
NATURE (2007)
Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
Xiankun Zeng et al.
FEBS LETTERS (2007)
An information-theoretic framework for resolving community structure in complex networks
Martin Rosvall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
Linda S. Kaltenbach et al.
PLOS GENETICS (2007)
Regional and cellular gene expression changes in human Huntington's disease brain
A Hodges et al.
HUMAN MOLECULAR GENETICS (2006)
Glial cell biology in Drosophila and vertebrates
MR Freeman et al.
TRENDS IN NEUROSCIENCES (2006)
Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform
MB Yaylaoglu et al.
DEVELOPMENTAL DYNAMICS (2005)
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
S Jamain et al.
NATURE GENETICS (2003)
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
YJ Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Identification of genes that modify ataxin-1-induced neurodegeneration
P Fernandez-Funez et al.
NATURE (2000)
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
A Yamamoto et al.
CELL (2000)