期刊
BIOMED RESEARCH INTERNATIONAL
卷 2021, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2021/6676502
关键词
-
资金
- National Research Foundation of Korea [NRF-2020R1F1A1070433]
- Technology Development Program - Ministry of SMEs and Startups (Korea) [S2519744]
- Gyeonggi Technology Development Program - Gyeonggi Province [D191972]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2519744] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study identified three new strains of Lactobacillus plantarum and investigated the antiobesogenic and antidiabetic effects of their extracts. The results showed that one of the extracts (L14) significantly reduced adipogenic differentiation and insulin resistance in vitro, suggesting its potential therapeutic use for obesity-associated metabolic disorders.
Obesity and associated metabolic disorders, including cardiovascular disease and diabetes, are rapidly becoming serious global health problems. It has been reported that Lactobacillus plantarum (L. plantarum) extracts have the beneficial activities of antiobesity and antidiabetes, although few studies have compared the beneficial effects among various L. plantarum extracts. In this study, three new L. plantarum (named LP, LS, and L14) strains were identified, and the antiobesogenic and diabetic effects of their extracts were investigated and compared using 3T3-L1 cells in vitro. Lipid accumulation in maturing 3T3-L1 cells was significantly decreased by the addition of LS and L14 extracts. The mRNA expression levels of Ppar gamma, C/ebp alpha, Fabp4, Fas, and Dgat1 were significantly decreased by the addition of LP, LS, and L14 extracts. Interestingly, the protein expression levels of PPAR gamma, C/EBP alpha, FABP4, and FAS were downregulated in mature 3T3-L1 cells with the addition of the L14 extract. Moreover, the LS and L14 extract treatments stimulated glucose uptake in maturing adipocytes. The L14 extract treatments exhibited a significant reduction in TNF-alpha protein expression, which is a key factor of insulin resistance in adipocytes. Of the three extracts, L14 extract markedly reduced adipogenic differentiation and insulin resistance in vitro, suggesting that the L14 extract may be used as a therapeutic agent for obesity-associated metabolic disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据