Transition Metal-Catalyzed Synthesis of 1,2-Diketones: An Overview

The 1,2-diketone structural motif is present in various natural products and compounds of biological significance. In addition, these compounds are frequently used as precursors or intermediates in several synthetically important organic transformations. The transition-metal catalysis plays an essential role for the generation of several carbon-carbon and carbon-heteroatom bonds to access diverse heterocyclic compounds. This metal-catalyzed approach has been frequently used for the synthesis of these valuable 1,2-diketones. This review summarizes the various approaches involving the transition metal-catalyzed synthesis of 1,2-diketones from easily accessible staring materials.

Automated summary

The 1,2-diketone structural motif is commonly found in natural products and biologically significant compounds, serving as precursors or intermediates in important organic transformations. Transition-metal catalysis is essential for generating carbon-carbon and carbon-heteroatom bonds to access diverse heterocyclic compounds, and has been frequently used for the synthesis of valuable 1,2-diketones from easily accessible starting materials.