期刊
EUROPEAN NEUROLOGY
卷 76, 期 1-2, 页码 28-34出版社
KARGER
DOI: 10.1159/000447536
关键词
Ischemic preconditioning; Small vessel disease; White matter lesions; Cognitive function; Dizziness
资金
- High-Level Health Technology Talent Construction Program of the Beijing Municipal Health Bureau [008-0019]
- Talent Cultivation Foundation
- Beijing Outstanding Talents Cultivation Fund
- Beijing Municipal Committee [2012D005018000007]
- Natural Science Foundation, Shanghai Jiao Tong University School of Medicine [YZ1006]
Background: Remote ischemic preconditioning (RIPC) of the limb has been shown to induce ischemic tolerance in basic and clinical studies that focused on sustained large artery occlusion rather than small vessel disease (SVD). This study aimed to evaluate the protective effects of brief repetitive limb RIPC on patients with cerebral SVD. Methods: Seventeen patients with cerebral SVD were enrolled. Patients underwent 5 ischemia-reperfusion cycles of preconditioning/sham preconditioning on both upper limbs twice a day for 1 year. Cerebral hemodynamic indexes, brain lesions, cognitive functions and assessment outcomes of dizziness handicap inventory (DHI) were analyzed. Results: In the RIPC group, the mean flow velocity (MFV) of the left middle cerebral artery (MCA) was accelerated (57.33 (52.3361.34) vs. 51.33 (48.83-58.33), respectively; p = 0.038), and the post-treatment DHI score was reduced (18 (13-19) vs. 34 (21-45), respectively; p = 0.043). The post-treatment volume of the white matter lesions (WMLs) was also reduced (4.19 (2.96-7.25) vs. 6.06 (4.67-10.95), respectively; p = 0.050). There was no remarkable difference between the 2 groups either before or after treatment. Conclusion: The present study indicates that RIPC has potential beneficial effects on cerebral SVD by increasing the MFV of MCA, decreasing the DHI score as well as the volume of WMLs in patients with SVD. (C) 2016 S. Karger AG, Basel
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