期刊
POLYMERS
卷 13, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/polym13091529
关键词
synergistic antibacterial effect; AgNP; tigecycline; A; baumannii; silver protein
资金
- Research Project of Ministry of Science and Technology, Taiwan [MOST 107-2221-E-037-001-MY3, MOST 109-2314-B-384-001]
- Special Research Project of Kaohsiung Medical University, Taiwan [KMU-TC108A03-7]
- Research Project of Chi Mei Medical Center and Kaohsiung Medical University Research Foundation, Taiwan [109CM-KMU-005]
- Special Research Project of Chi Mei Medical Centre, Taiwan [CMFHR 10888]
- Research Cooperation Project of Kaohsiung Medical University and Changhua Christian Hospital, Changhua Christian Medical Foundation, Taiwan [108-CCH-KMU-007]
The combination of silver protein and tigecycline showed a synergistic effect in inhibiting the viability of A. baumannii, with significantly lower minimum inhibitory concentrations compared to individual MICs and a calculated combination index of 0.59. This integrated antibacterial strategy could provide a promising approach for the treatment of A. baumannii infections.
Acinetobacter baumannii (A. baumannii) is a common and challenging pathogen of nosocomial infections, due to its ability to survive on inanimate objects, desiccation tolerance, and resistance to disinfectants. In this study, we investigated an antibacterial strategy to combat A. baumannii via the combination of antibiotics and silver protein. This strategy used a functional platform consisting of silver nanoparticles (AgNPs) resurrected from silver-based calcium thiophosphate (SSCP) through casein and arginine. Then, the silver protein was combined with tigecycline, the first drug in glycylcycline antibiotic, to synergistically inhibit the viability of A. baumannii. The synergistic antibacterial activity was confirmed by the 96-well checkerboard method to determine their minimum inhibitory concentrations (MIC) and calculated for the combination index (CI). The MIC of the combination of silver protein and tigecycline (0.31 mg/mL, 0.16 mu g/mL) was significantly lower than that of the individual MIC, and the CI was 0.59, which indicates a synergistic effect. Consequently, we integrated the detailed synergistic antibacterial properties when silver protein was combined with tigecycline. The result could make for a promising approach for the treatment of A. baumannii.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据