期刊
POLYMERS
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/polym13071042
关键词
tumor microenvironment; 3D matrix; multicellular spheroid; polymer complex; migration
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2018R1C1B6002333]
- National Research Foundation of Korea [2018R1C1B6002333] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study demonstrates the use of multicellular spheroids and self-assembled structures in a 3D matrix to mimic the tumor microenvironment, highlighting the importance of tumor complexities such as various cell types and microenvironments.
Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled structure, which provides a biocompatible 3D environment for the cells. Multicellular spheroids were formed on the optimized plate and were observed as cell migration from a spheroid within a 3D matrix, such as the invasive and metastatic cancer of TME. This study suggests a new 3D platform using polymer complexes and the importance of tumor complexities, including various cell types and microenvironments.
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