期刊
POLYMERS
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/polym13071133
关键词
conductive hydrogels; alginate; self-healing; stretchability; biocompatibility; electromyogram; dynamic covalent bonds; epigallocatechin gallate
资金
- National R&D Program for Cancer Control, Ministry of Health andWelfare, Republic of Korea [HA16C0016]
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2020R1C1C1003903, 2020R1C1C1005567]
- Korea Medical Device Development Fund - Korean government (Ministry of Science and ICT) [202012D28]
- Korea Medical Device Development Fund - Korean government (Ministry of Trade, Industry and Energy) [202012D28]
- Korea Medical Device Development Fund - Korean government (Ministry of Health Welfare) [202012D28]
- Korea Medical Device Development Fund - Korean government (Ministry of Food and Drug Safety) [202012D28]
- National Research Foundation of Korea [KMDF_PR_20200901_0136-01, 2020R1C1C1005567] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The article introduces a plant-inspired conductive alginate hydrogel composed of boronic acid modified alginate and oligomerized epigallocatechin gallate extracted from plant compounds. The conductive hydrogels exhibit high stretchability and self-healing properties, suitable for electrophysiological bridging to transfer electromyographic signals in an ex vivo muscle defect model.
Implantable electronics have recently been attracting attention because of the promising advances in personalized healthcare. They can be used to diagnose and treat chronic diseases by monitoring and applying bioelectrical signals to various organs. However, there are challenges regarding the rigidity and hardness of typical electronic devices that can trigger inflammatory reactions in tissues. In an effort to improve the physicochemical properties of conventional implantable electronics, soft hydrogel-based platforms have emerged as components of implantable electronics. It is important that they meet functional criteria, such as stretchability, biocompatibility, and self-healing. Herein, plant-inspired conductive alginate hydrogels composed of boronic acid modified alginate and oligomerized epigallocatechin gallate, which are extracted from plant compounds, are proposed. The conductive hydrogels show great stretchability up to 500% and self-healing properties because of the boronic acid-cis-diol dynamic covalent bonds. In addition, as a simple strategy to increase the electrical conductivity of the hydrogels, ionically crosslinked shells with cations (e.g., sodium) were generated on the hydrogel under physiological salt conditions. This decreased the resistance of the conductive hydrogel down to 900 ohm without trading off the original properties of stretchability and self-healing. The hydrogels were used for electrophysiological bridging to transfer electromyographic signals in an ex vivo muscle defect model, showing a great bridging effect comparable to that of a muscle-to-muscle contact model. The use of plant-inspired ionically conductive hydrogels is a promising strategy for designing implantable and self-healable bioelectronics.
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