Interaction of Diphenhydramine Hydrochloride with Cationic and Anionic Surfactants: Mixed Micellization and Binding Studies

The focus of the present work is to evaluate the interactions of an anti-allergic drug (diphenhydramine hydrochloride, DPH) with anionic (sodium dodecyl sulfate, SDS) and cationic (cetylpyridinium chloride, CPC) surfactants in the aqueous medium. The mixed micellization behavior and surface properties of drug-surfactant mixtures have been examined by surface tension measurements. Various theoretical approaches were applied to explore the synergistic or non-ideal behavior of the current mixed systems. Furthermore, the binding studies of drug with surfactants have been elaborated by UV-visible spectroscopy. Benesi-Hildebrand (B-H) theory was used to compute stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures. The outputs are deliberated taking into consideration the use of surfactants as capable drug delivery agents for DPH and hence advance bioavailability.

Automated summary

The study evaluated the interactions between an anti-allergic drug and anionic and cationic surfactants in aqueous medium, examining mixed micellization behavior and surface properties. Theoretical approaches were used to explore synergistic or non-ideal behavior, and binding studies were elaborated by UV-visible spectroscopy. Benesi-Hildebrand theory was applied to calculate stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures, considering the use of surfactants as drug delivery agents for enhanced bioavailability.