期刊
POLYMERS
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/polym13060932
关键词
alginate; gelatin; 2-hydroxyethyl methacrylate; hydroxyapatite; hydrogel scaffolding biomaterial; degradable scaffolds; biocompatibility; tissue regeneration engineering
资金
- SCOPES program of the Swiss National Science Foundation (SNSF)
- Swiss Agency for Development and Cooperation (SDC) [IZ73ZO_152327]
- Ministry for Education, Science and Technological Development of the Republic of Serbia [451-03-9/2021-14/172062, 451-03-9/2021-14/172026]
Hydrogel scaffolding biomaterials mimic the native extracellular matrix, and novel hydrogel scaffolds prepared using modified cryogelation show promising properties in terms of microstructure, mechanical strength, and biocompatibility. These newly synthesized hydrogel scaffolds have potential for versatile biomedical applications and tissue regeneration.
Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.
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