期刊
POLYMERS
卷 13, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/polym13081244
关键词
chitosan; nanocomposites; drug delivery; biomedical applications; microencapsulation
资金
- project Fondecyt [1140025]
Microcapsules based on chitosan and including nano-magnetite and erlotinib were synthesized and characterized by SEM, FT-IR, and TGA. The encapsulation percentage was determined, showing bacteriostatic properties. The HPLC analysis indicated a 52% encapsulation rate, and the encapsulated drug exhibited lower effectiveness and toxicity in vitro studies compared to the non-encapsulated drug.
Microcapsules (MC) based on chitosan (CH) and including nano-magnetite and erlotinib were synthesized. The microparticles were characterized by SEM, FT-IR and TGA. The percentage of encapsulation was determined, as well as its microbiological activity. Finally, the effectiveness of the formulation was evaluated in terms of cell viability and/or toxicity when compared with the reference drug. The formulation used to prepare the microcapsules showed some bacteriostatic properties. The characterization of microcapsules exhibited amorphous spherical shape and average size of 1.29, 1.58 and 1.62 mm for chitosan, chitosan + nanomagnetite and chitosan + nanomagnetite + erlotinib, respectively. The infrared spectra showed characteristic bands of the erlotinib and magnetite, confirming its internalization. The thermogravimetric analyzes indicated that the materials do not undergo changes at optimum working temperatures. The HPLC analysis showed a 52% of encapsulation. Finally, the formulation probed had lower effectiveness and less cytotoxicity, than the drug without encapsulating in vitro studies. For that reason several assays are in progress.
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