期刊
JOURNAL OF GINSENG RESEARCH
卷 46, 期 1, 页码 138-146出版社
KOREAN SOC GINSENG
DOI: 10.1016/j.jgr.2021.05.005
关键词
Rg3-RGE (Rg3-enriched red ginseng extract); apoptosis; mitophagy; PINK1-parkin signaling
资金
- Korean Society of Ginseng
Rg3-RGE exhibits anti-proliferative and pro-apoptotic effects in lung cancer cells, accompanied by increased expression of mitophagy-related proteins. Combination treatment of Rg3-RGE with mitophagy inhibitors leads to cell death.
Background: Red Ginseng has been used for many years to treat diseases. Ginsenoside Rg3 has documented therapeutic effects, including anticancer and anti-inflammatory activities. However, the anticancer effect of Rg3-enriched red ginseng extract (Rg3-RGE) and its underlying mechanisms have not been fully explored. We investigated whether Rg3-RGE plays an anti-tumor role in lung cancer cells. Methods: To examine the effect of Rg3-RGE on lung cancer cells, we performed cell viability assays, flow cytometry, western blotting analysis, and immunofluorescence to monitor specific markers. Results: Rg3-RGE significantly inhibited cell proliferation and induced mitochondria-dependent apoptosis. Furthermore, Rg3-RGE also increased expression of mitophagy-related proteins such as PINK1 and Parkin. In addition, treatment with Rg3-RGE and mitophagy inhibitors stimulated cell death by inducing mitochondria dysfunction. Conclusions: Rg3-RGE could be used as a therapeutic agent against lung cancer. (c) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据