期刊
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
卷 19, 期 5, 页码 510-516出版社
ELSEVIER BRAZIL
DOI: 10.1016/j.bjid.2015.06.011
关键词
MicroRNAs; Enterovirus; Infection
资金
- Science and Technology Support Program (Social Development) of Zhenjiang, Jiangsu Province 333 Project [SH2012052]
The genus Enterooirus, a member of the Picornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection of Enterooirus, such as enterovirus 71, coxsackievirus B3 and other Enterooirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection. (C) 2015 Elsevier Editora Ltda. All rights reserved.
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