期刊
出版社
MDPI
DOI: 10.3390/ijerph18073627
关键词
obesity; early years; collagen; inflammation; macrophages; adipose tissue
资金
- Faculty of Medicine Josip Juraj Strossmayer, University of Osijek [VIF2017-MEFOS-9]
- Faculty of Dental Medicine and Health Josip Juraj Strossmayer, University of Osijek [VIF-2018-FDMZOS05]
- Faculty of Dental Medicine and Health Science Fund
The study examined adipose tissue remodeling in healthy male children based on weight status. Results showed that obese children had higher triglyceride levels, larger adipocyte size, more collagen in subcutaneous adipose tissue, crown-like structures in fat tissues, and more CD163(+) cells in visceral adipose tissue. Obesity in male children leads to hypertrophy of adipocytes, increased collagen deposition in subcutaneous adipose tissues, and changes in macrophage polarization and accumulation.
Childhood obesity is a complex health problem, and not many studies have been done on adipose tissue remodeling in early childhood. The aim of this study was to examine extracellular matrix remodeling in the adipose tissue of healthy male children depending on their weight status. Subcutaneous and visceral adipose tissue was obtained from 45 otherwise healthy male children who underwent elective surgery for hernia repairs or orchidopexy. The children were divided into overweight/obese (n = 17) or normal weight groups (n = 28) depending on their body mass index (BMI) z-score. Serum was obtained for glucose, testosterone, triglyceride, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) measurements. Sections of adipose tissue were stained with hematoxylin and eosin to determine the adipocytes' surface area, and Masson's trichrome stain was used to detect the adipocytes' collagen content. Immunohistochemistry for CD163(+) cells was also performed. The results showed that male children in the overweight group had higher serum triglyceride levels, greater adipocyte surface area and collagen content in their subcutaneous adipose tissue, more crown-like structures in fat tissues, and more CD163(+) cells in their visceral adipose tissue than males in the normal weight group. In conclusion, in male children, obesity can lead to the hypertrophy of adipocytes, increased collagen deposition in subcutaneous adipose tissues, and changes in the polarization and accumulation of macrophages.
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