期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 17, 期 8, 页码 2471-2481出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2021.1891752
关键词
Yellow Fever vaccination; Immune response; T cells; B cells
资金
- Swiss National Science Foundation (SNF) [310030-179459]
- Quealth Foundation
- University of Lausanne
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung (CH) [310030-179459]
- Swiss National Science Foundation (SNF) [310030_179459] Funding Source: Swiss National Science Foundation (SNF)
Vaccines play a significant role in preventing infectious diseases and offer valuable insights into human immune responses, particularly live-attenuated virus vaccines.
By preventing infectious diseases, vaccines contribute substantially to public health. Besides, they offer great opportunities to investigate human immune responses. This is particularly true for live-attenuated virus vaccines which cause resolving acute infections and induce robust immunity. The fact that one can precisely schedule the time-point of vaccination enables complete characterization of the immune response over time, short-term and over many years. The live-attenuated Yellow Fever virus vaccine strain YF-17D was developed in the 1930's and gave rise to the 17D-204 and 17DD vaccine sub-strains, administered to over 600 million individuals worldwide. YF vaccination causes a systemic viral infection, which induces neutralizing antibodies that last for a lifetime. It also induces a strong T cell response resembling the ones of acute infections, in contrast to most other vaccines. In spite of its use since 1937, learning how YF vaccination stimulates such strong and persistent immune responses has gained substantial knowledge only in the last decades. Here we summarize the current state of knowledge on the immune response to YF vaccination, and discuss its contribution as a human model to address complex questions on optimal immune responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据