4.7 Article

Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study

期刊

GENOME MEDICINE
卷 13, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s13073-021-00865-3

关键词

Childhood BMI; Mendelian randomization; Adult outcome; Causal

资金

  1. National Natural Science Foundation of China [31871264, 32070588]
  2. Natural Science Foundation of Zhejiang Province [LWY20H060001]
  3. Fundamental Research Funds for the Central Universities

向作者/读者索取更多资源

The study identified potential causal effects of childhood obesity on 60 adult traits, but found that the detrimental effects on disease-related traits were no longer present after accounting for adult BMI. The associations between childhood BMI and increased risks of diseases in adulthood are likely attributed to individuals remaining obese in later life.
BackgroundChildhood obesity is reported to be associated with the risk of many diseases in adulthood. However, observational studies cannot fully account for confounding factors. We aimed to systematically assess the causal associations between childhood body mass index (BMI) and various adult traits/diseases using two-sample Mendelian randomization (MR).MethodsAfter data filtering, 263 adult traits genetically correlated with childhood BMI (P<0.05) were subjected to MR analyses. Inverse-variance weighted, MR-Egger, weighted median, and weighted mode methods were used to estimate the causal effects. Multivariable MR analysis was performed to test whether the effects of childhood BMI on adult traits are independent from adult BMI.ResultsWe identified potential causal effects of childhood obesity on 60 adult traits (27 disease-related traits, 27 lifestyle factors, and 6 other traits). Higher childhood BMI was associated with a reduced overall health rating (=-0.10, 95% CI -0.13 to -0.07, P=6.26x10(-11)). Specifically, higher childhood BMI was associated with increased odds of coronary artery disease (OR=1.09, 95% CI 1.06 to 1.11, P=4.28x10(-11)), essential hypertension (OR=1.12, 95% CI 1.08 to 1.16, P=1.27x10(-11)), type 2 diabetes (OR=1.36, 95% CI 1.30 to 1.43, P=1.57x10(-34)), and arthrosis (OR=1.09, 95% CI 1.06 to 1.12, P=8.80x10(-9)). However, after accounting for adult BMI, the detrimental effects of childhood BMI on disease-related traits were no longer present (P>0.05). For dietary habits, different from conventional understanding, we found that higher childhood BMI was associated with low calorie density food intake. However, this association might be specific to the UK Biobank population.ConclusionsIn summary, we provided a phenome-wide view of the effects of childhood BMI on adult traits. Multivariable MR analysis suggested that the associations between childhood BMI and increased risks of diseases in adulthood are likely attributed to individuals remaining obese in later life. Therefore, ensuring that childhood obesity does not persist into later life might be useful for reducing the detrimental effects of childhood obesity on adult diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据