Modeling longitudinal changes in hippocampal subfields and relations with memory from early- to mid-childhood

The hippocampus has been suggested to show protracted postnatal developmental growth across childhood. Most previous studies during this developmental period have been cross-sectional in nature and have focused on agerelated differences in either hippocampal subregions or subfields, but not both, potentially missing localized changes. This study capitalized on a latent structural equation modeling approach to examine the longitudinal development of hippocampal subfields (cornu ammonis (CA) 2-4/dentate gyrus (DG), CA1, subiculum) in both the head and the body of the hippocampus, separately, in 165 typically developing 4- to 8-year-old children. Our findings document differential development of subfields within hippocampal head and body. Specifically, within hippocampal head, CA1 volume increased between 4-5 years and within hippocampal body, CA2-4/DG and subiculum volume increased between 5-6 years. Additionally, changes in CA1 volume in the head and changes in subiculum in the body between 4-5 years related to improvements in memory between 4-5 years. These findings demonstrate the protracted development of subfields in vivo during early- to mid-childhood, illustrate the importance of considering subfields separately in the head and body of the hippocampus, document cooccurring development of brain and behavior, and highlight the strength of longitudinal data and latent modeling when examining brain development.

Automated summary

The hippocampus shows differential development of subfields within the head and body across early- to mid-childhood. Changes in volume of certain subfields within specific age ranges are related to improvements in memory, highlighting the importance of considering subfields separately in the hippocampus. This study emphasizes the protracted development of subfields in vivo during childhood, the cooccurring development of brain and behavior, and the strength of longitudinal data and latent modeling in examining brain development.