期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 48, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2021.100951
关键词
Fetal alcohol spectrum disorder; Prenatal alcohol exposure; Resting-state functional MRI; Functional connectivity; Attention; Executive function
资金
- Kids Brain Health Network (KBHN)
- Killam Postdoctoral Fellowship award
This study found that prenatal alcohol exposure is associated with cognitive and functional brain alterations in children. Compared to controls, children with PAE showed both reduced and increased functional connectivity within and between attention networks, indicating inefficient network specialization and impaired long-range connections among attention network regions.
Cognitive and functional brain alterations can occur in children with prenatal alcohol exposure (PAE). We examined the functional connectivity (FC) among regions within and between attention networks, and whether inter- and intranetwork FC moderated cognition in children with PAE (n = 37; age 12.8 ? 2.8 years) and nonexposed controls (n = 40; age 13.2 ? 2.8 years). Participants completed standardized attention and executive functioning tasks and resting state functional MRI. Inter- and intra-network FC and graph-theoretical metrics were calculated among attention network regions. Relative to controls, PAE was associated with reduced FC between the left temporoparietal junction and left ventral frontal cortex and anterior insula/frontal operculum (aI/fO), and between the left intraparietal sulcus and bilateral aI/fO. PAE was associated with increased FC between the right precuneus and intraparietal lobes, the right anterior prefrontal cortex and left ventral frontal cortex and aI/fO, and the left thalamus and dorsal frontal cortex. Graph-theoretical metrics did not differ by group. FC predicted cognitive performance, negatively in the children with PAE and positively in controls. Increased intra-network together with reduced internetwork FC suggests inefficient network specialization and impaired long-range FC among attention network regions after PAE. Results further suggest that those alterations may underlie attention and executive dysfunction in children with PAE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据