相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019
Martin Martinot et al.
CLINICAL INFECTIOUS DISEASES (2021)
Repurposed Antiviral Drugs for Covid-19-Interim WHO Solidarity Trial Results
NEW ENGLAND JOURNAL OF MEDICINE (2021)
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Goran Kokic et al.
NATURE COMMUNICATIONS (2021)
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19
Steven S. Good et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir
Ross Martin et al.
ANTIVIRAL RESEARCH (2021)
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
Jack P. K. Bravo et al.
MOLECULAR CELL (2021)
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex
Brandon Malone et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19
Brian T. Garibaldi et al.
JAMA NETWORK OPEN (2021)
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Manli Wang et al.
CELL RESEARCH (2020)
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
Calvin J. Gordon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase
Quan Wang et al.
CELL (2020)
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
Calvin J. Gordon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Wanchao Yin et al.
SCIENCE (2020)
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
Timothy P. Sheahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
Richard T. Eastman et al.
ACS CENTRAL SCIENCE (2020)
Structure of replicating SARS-CoV-2 polymerase
Hauke S. Hillen et al.
NATURE (2020)
Remdesivir for the Treatment of Covid-19-Final Report
John H. Beigel et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
James Chen et al.
CELL (2020)
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Brandi N. Williamson et al.
NATURE (2020)
Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
Andrea J. Pruijssers et al.
CELL REPORTS (2020)
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
Egor P. Tchesnokov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting (vol 79, pg 710, 2020)
Fran Robson et al.
MOLECULAR CELL (2020)
FDA Approval of Remdesivir - A Step in the Right Direction
Daniel Rubin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report
Matthew S. Buckland et al.
NATURE COMMUNICATIONS (2020)
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase
Tyler L. Dangerfield et al.
ISCIENCE (2020)
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Egor P. Tchesnokov et al.
VIRUSES-BASEL (2019)
Nucleoside analogues for the treatment of coronavirus infections
Andrea J. Pruijssers et al.
CURRENT OPINION IN VIROLOGY (2019)
Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
Robert N. Kirchdoerfer et al.
NATURE COMMUNICATIONS (2019)
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics
Sabue Mulangu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Maria L. Agostini et al.
MBIO (2018)
Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
Paul C. Jordan et al.
PLOS PATHOGENS (2018)
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Timothy P. Sheahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Michael K. Lo et al.
SCIENTIFIC REPORTS (2017)
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren et al.
NATURE (2016)
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
Lorenzo Subissi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity
Han Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
Aesop Cho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
RNA 3′-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
Mickael Bouvet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Mechanism matters
[Anonymous]
NATURE MEDICINE (2010)
Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase
Egor P. Tchesnokov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation
Bruno Marchand et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases
PL Boyer et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase -: Implications for polymerase translocation and drug resistance
B Marchand et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)