期刊
CELL REPORTS
卷 35, 期 4, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109033
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资金
- Canadian Institutes of Health Research (CIHR) - CIHR
- Canada-Israel Health Research Initiative - CIHR
- Israel Science Foundation
- International Development Research Centre
- Azrieli Foundation
- Canada Research Chair
- Alberta Innovates
Neuropathic pain is a challenging condition with limited treatment options. This study highlights the modulatory role of the ventrolateral orbitofrontal cortex (vlOFC) in neuropathic pain, demonstrating that specific activation of vlOFC neurons can inhibit hypersensitivity. Targeting this pathway could potentially offer relief for patients suffering from neuropathic pain.
Neuropathic pain is a debilitating condition that is often refractory to treatment. The network of neural substrates for pain transmission and control within the brain is complex and remains poorly understood. Through a combination of neuronal tracing, optogenetics, chemogenetics, electrophysiological recordings, and behavioral assessment, we demonstrate that activation of layer 5 pyramidal neurons in the ventrolateral orbitofrontal cortex (vlOFC) attenuates mechanical and thermal hypersensitivity and cold allodynia in mice with neuropathic pain induced by spared nerve injury (SNI). These vlOFC output neurons project to the posterior ventrolateral periaqueductal gray (vlPAG) region and receive inputs from the ventromedial thalamus (VM). Specific optogenetic and chemogenetic activation of the vlOFC-vlPAG and the VM-vlOFC circuits inhibits hypersensitivity associated with neuropathy. Thus, we reveal a modulatory role of the vlOFC and its projections to the vlPAG circuit in the processing of hypersensitive nociception.
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