期刊
CELL REPORTS
卷 35, 期 5, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109085
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资金
- Vanderbilt University Medical Scientist Training Program [T32GM007347]
- National Institutes of Health [F30HL143826, R35HG010718, R01HG011138, R01GM140287, R01HL133559]
- Clare Hall, University of Cambridge (UK)
- Washington University Institute of Clinical and Translational Sciences grant from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) [UL1TR002345]
- NIH/NINDS [K23NS075151]
- Vanderbilt Institute for Clinical and Translational Research (VICTR) [VR52639]
Research findings show that decreased expression of MAEL in the brain is significantly associated with hydrocephalus risk, with MAEL expression in the frontal cortex being correlated with white matter and total brain volumes. Enrichment of top differentially expressed genes in brain for gene-level associations with structural phenotypes suggests an impact on disease risk through regulation of brain structure and integrity.
We conducted PrediXcan analysis of hydrocephalus risk in ten neurological tissues and whole blood. Decreased expression of MAEL in the brain was significantly associated (Bonferroni-adjusted p < 0.05) with hydrocephalus. PrediXcan analysis of brain imaging and genomics data in the independent UK Biobank (N = 8,428) revealed that MAEL expression in the frontal cortex is associated with white matter and total brain volumes. Among the top differentially expressed genes in brain, we observed a significant enrichment for gene-level associations with these structural phenotypes, suggesting an effect on disease risk through regulation of brain structure and integrity. We found additional support for these genes through analysis of the choroid plexus transcriptome of a murine model of hydrocephalus. Finally, differential protein expression analysis in patient cerebrospinal fluid recapitulated disease-associated expression changes in neurological tissues, but not in whole blood. Our findings provide convergent evidence highlighting the importance of tissue-specific pathways and mechanisms in the pathophysiology of hydrocephalus.
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