期刊
CELL REPORTS
卷 35, 期 5, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109082
关键词
-
类别
资金
- National Institute of Mental Health [F30MH110084]
- Klingenstein-Simons
- MQ
- NARSAD
- Whitehall
- National Institute on Drug Abuse [R01DA042038]
- National Institute of Neurological Disorders and Stroke [R01NS104834]
- NINDS [P30NS050274]
The study investigates the mechanisms behind persistent activity changes in the prefrontal cortex of mice during behaviors that involve reward predictions. The researchers found that reward-predictive persistent firing increases in specific layers and cell types, conveying information about internal state through synaptic mechanisms.
Nervous systems maintain information internally using persistent activity changes. The mechanisms by which this activity arises are incompletely understood. We study prefrontal cortex (PFC) in mice performing behaviors in which stimuli predicted rewards at different delays with different probabilities. We measure membrane potential (V-m) from pyramidal neurons across layers. Reward-predictive persistent firing increases arise due to sustained increases in mean and variance of V m and are terminated by reward or via centrally generated mechanisms based on reward expectation. Other neurons show persistent decreases in firing rates, maintained by persistent hyperpolarization that is robust to intracellular perturbation. Persistent activity is layer (L)- and cell-type-specific, Neurons with persistent depolarization are primarily located in upper L5, whereas those with persistent hyperpolarization are mostly found in lower L5. L2/3 neurons do not show persistent activity. Thus, reward-predictive persistent activity in PFC is spatially organized and conveys information about internal state via synaptic mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据