期刊
CELL REPORTS
卷 34, 期 12, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.108874
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资金
- National Institutes of Health, United States [MH108842]
Exposure to prolonged stress during critical developmental periods increases the risk of psychiatric disorders and may lead to sex-specific consequences. Studying mice subjected to chronic adolescent social isolation stress, it was found that stressed males exhibit escalated aggression while stressed females show social withdrawal. In-depth analysis of neuronal circuits revealed different physiological mechanisms contributing to these sex-specific divergent effects of stress.
Exposure to prolonged stress in critical developmental periods induces heightened vulnerability to psychiatric disorders, which may have sex-specific consequences. Here we investigate the neuronal circuits mediating behavioral changes in mice after chronic adolescent social isolation stress. Escalated aggression is exhibited in stressed males, while social withdrawal is shown in stressed females. In vivo multichannel recordings of free-moving animals indicate that pyramidal neurons in prefrontal cortex (PFC) from stressed males exhibit the significantly decreased spike activity during aggressive attacks, while PFC pyramidal neurons from stressed females show a blunted increase of discharge rates during sociability tests. Chemogenetic and electrophysiological evidence shows that PFC hypofunctioning and BLA principal neuron hyperactivity contribute to the elevated aggression in stressed males, while PFC hypofunctioning and VTA dopamine neuron hypoactivity contribute to the diminished sociability in stressed females. These results establish a framework for understanding the circuit and physiological mechanisms underlying sex-specific divergent effects of stress.
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