期刊
CELL REPORTS
卷 35, 期 7, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109129
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资金
- Foundation pour la recherche Medicale'' (FRM)
- Labex international PhD fellowship from IGBMC
- IGBMC
- CNRS
- Fondation ARC pour la Recherche sur le Cancer (ARC)
- Institut National Du Cancer (INCa)
- Ligue Nationale contre le Cancer
- USIAS
- Sanofi iAward Europe
- FRM
- Agence Nationale de la Recherche (ANR)
- European Foundation for the Study of Diabetes (EFSD)/Novo Nordisk Diabetes Research
This study reveals a pathway linking mitochondrial fission to mitotic progression in mammalian cells, showing that PKD/MFF-dependent mitochondrial fission is essential for chromosome segregation and cell survival during cell division.
Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression remains largely unknown. Here, we discover a pathway linking mitochondrial fission to mitotic progression in mammalian cells. The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells. Phosphorylation of MFF is crucial for chromosome segregation and promotes cell survival by inhibiting adaptation of the mitotic checkpoint. Thus, PKD/MFF-dependent mitochondrial fission is critical for the maintenance of genome integrity during cell division.
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