期刊
CANCER RESEARCH AND TREATMENT
卷 53, 期 4, 页码 1042-1056出版社
KOREAN CANCER ASSOCIATION
DOI: 10.4143/crt.2020.1208
关键词
LncRNA; KCNQ1OT1; Small cell lung cancer; Prognostic; Chemotherapy
类别
资金
- Natural Science Foundation of Guang-dong Province [2016A030313137]
- Special Grant for Education and Scientific Research of Fujian Provincial Department of Finance (Fujian Finance Document) [(2019) 926]
This study reveals that upregulated expression of KCNQ1OT1 in SCLC is associated with poor prognosis. Knockdown of KCNQ1OT1 inhibits proliferation, migration, chemoresistance, and promotes apoptosis in SCLC cells. KCNQ1OT1 may activate Transforming Growth Factor-beta 1 mediated epithelial-to-mesenchymal transition in SCLC cells.
Purpose Drug resistance is one of the main causes of chemotherapy failure in patients with small cell lung cancer (SCLC), and extensive biological studies into chemotherapy drug resistance are required. Materials and Methods In this study, we performed lncRNA microarray, in vitro functional assays, in vivo models and cDNA microarray to evaluate the impact of lncRNA in SCLC chemoresistance. Results The results showed that KCNQ1OT1 expression was upregulated in SCLC tissues and was a poor prognostic factor for patients with SCLC. Knockdown of KCNQ1OT1 inhibited cell proliferation, migration, chemoresistance and promoted apoptosis of SCLC cells. Mechanistic investigation showed that KCNQ1OT1 can activate transforming growth factor-beta 1 mediated epithelial-tomesenchymal transition in SCLC cells. Conclusion Taken together, our study revealed the role of KCNQ1OT1 in the progression and chemoresistance of SCLC, and suggested KCNQ1OT1 as a potential diagnostic and prognostic biomarker in SCLC clinical management.
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