4.7 Article

3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution

期刊

ADVANCED HEALTHCARE MATERIALS
卷 10, 期 12, 页码 -

出版社

WILEY
DOI: 10.1002/adhm.202100117

关键词

3D printing; biomaterials; bone substitutes; hybrids; sol‐ gels

资金

  1. EPSRC [EP/M019950/1]
  2. National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT) [NRF-2020R1C1C1012881, 2021R1A2C2004634]
  3. KIST institutional program [2E30341, 2E31251]
  4. UK Regenerative Medicine Platform Acellular/Smart Materials - 3D Architecture [MR/R015651/1]
  5. National Research Foundation of Korea [2021R1A2C2004634] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  6. EPSRC [EP/M019950/1] Funding Source: UKRI
  7. MRC [MR/R015651/1] Funding Source: UKRI

向作者/读者索取更多资源

Inorganic-organic hybrid biomaterials made with star polymer and silica are successfully 3D printed as bone substitutes, showing promising mechanical properties. The hybrid scaffolds are able to promote osteoblast cell adhesion in vitro and demonstrate osteogenic and angiogenic properties in a rat model.
Inorganic-organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica(,) which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate)-star-SiO2 hybrid inks are printed with pore channels in the range of 100-200 mu m. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre-osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic-organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials.

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