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Mesenchymal stem cells and extracellular vesicles in therapy against kidney diseases

期刊

STEM CELL RESEARCH & THERAPY
卷 12, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s13287-021-02289-7

关键词

Kidney diseases; Mesenchymal stem cells; Extracellular vesicles

资金

  1. National Natural Science Foundation of China [81970663]
  2. Natural Science Foundation of Liaoning Province [2019-BS-277]

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MSC-EVs have demonstrated significant therapeutic effects on acute kidney injury, chronic kidney disease, diabetic nephropathy, and atherosclerotic renovascular disease, while their roles in transplanted kidneys remain controversial.
Kidney diseases pose a threat to human health due to their rising incidence and fatality rate. In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells (MSCs) are effective and safe when used to treat kidney diseases. MSCs play their role mainly by secreting trophic factors and delivering extracellular vesicles (EVs). The genetic materials and proteins contained in the MSC-derived EVs (MSC-EVs), as an important means of cellular communication, have become a research focus for targeted therapy of kidney diseases. At present, MSC-EVs have shown evident therapeutic effects on acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN), and atherosclerotic renovascular disease (ARVD); however, their roles in the transplanted kidney remain controversial. This review summarises the mechanisms by which MSC-EVs treat these diseases in animal models and proposes certain problems, expecting to facilitate corresponding future clinical practice.

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