Algal magnetic nickel oxide nanocatalyst in accelerated synthesis of pyridopyrimidine derivatives

This research presents a novel biological route for the biosynthesis of nickel oxide nanoparticles (NiO NPs) using marine macroalgae extract as a reducing and coating agent under optimized synthesis conditions. XRD and TEM analyses revealed that phytosynthesized NiO NPs are crystalline in nature with a spherical shape having a mean particle size of 32.64 nm. TGA results indicated the presence of marine-derived organic constituents on the surface of NiO NPs. It is found that biogenic NiO NPs with BET surface area of 45.59 m(2)g(-1) is a highly efficient catalyst for benign one-pot preparation of pyridopyrimidine derivatives using aqueous reaction conditions. This environmentally friendly procedure takes considerable advantages of shorter reaction times, excellent product yields (up to 96%), magnetically viable nanocatalyst (7 runs), low catalyst loadings, and free toxic chemical reagents.

Automated summary

This research successfully synthesized nickel oxide nanoparticles using marine macroalgae extract as a reducing and coating agent, demonstrating excellent catalytic performance for the efficient preparation of bioactive compounds. The study suggests that the use of biogenic nanoparticles for organic synthesis can achieve environmentally friendly and efficient methods.