4.7 Article

Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry

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Review Clinical Neurology

Contemporary functional neuroanatomy and pathophysiology of dystonia

Norbert Brueggemann

Summary: Dystonia is a movement disorder characterized by abnormal postures or movement patterns, with pathophysiological mechanisms including impaired sensorimotor integration, loss of inhibitory control on multiple levels of the central nervous system, and changes in synaptic plasticity. In addition to traditional views involving the basal ganglia, studies also highlight the role of the cerebellum, cerebello-thalamic connections, and the interplay between the basal ganglia and cerebellum in dystonia's pathophysiology. Other emerging topics include understanding the microarchitecture of the striatum and its implications for dystonia.

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