期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 85, 期 10, 页码 1708-1715出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2016.07.012
关键词
Thin-section CT; Pure ground-glass opacity; Focal interstitial fibrosis; Atypical adenomatous hyperplasia; Adenocarcinoma in situ; Minimally invasive adenocarcinoma
资金
- Health and Family Planning Commission of Shanghai, China
Objective: To retrospectively compare focal interstitial fibrosis (FIF), atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), and minimally invasive adenocarcinoma (MIA) with pure ground glass opacity (GGO) using thin-section computed tomography (CT). Materials and methods: Sixty pathologically confirmed cases were reviewed including 7 cases of FIF, 17 of AAH, 23of AIS, and 13 of MIA. All nodules kept pure ground glass appearances before surgical resection and their last time of thin-section CT imaging data before operation were collected. Differences of patient demographics and CT features were compared among these four types of lesions. Results: FIF occurred more frequently in males and smokers while the others occurred more frequently in female nonsmokers. Nodule size was significant larger in MIA (P < 0.001, cut-off value = 7.5 mm). Nodule shape (P=0.045), margin characteristics (P < 0.001), the presence of pleural indentation (P=0.032), and vascular ingress (P < 0.001) were significant factors that differentiated the 4 groups. A concave margin was only demonstrated in a high proportion of FIF at 85.7% (P=0.002). There were no significant differences (all P> 0.05) in age, malignant history, attenuation value, location, and presence of bubble-like lucency. Conclusion: A nodule size >7.5 mm increases the possibility of MIA. A concave margin could be useful for differentiation of FIF from the other malignant or pre-malignant GGO nodules. The presence of spiculation or pleural indentation may preclude the diagnosis of AAH. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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