期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-87985-3
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资金
- UiT The Arctic University of Norway
High expression of miR-126 is associated with increased disease-specific survival in colon cancer patients, and it is an independent predictor of improved disease-specific survival in tumor tissue. This finding of miR-126 as a positive prognostic factor may help identify patients who could benefit from adjuvant chemotherapy.
miR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I-III colon cancer was retrospectively collected and tissue microarrays were constructed. miR-126 expression was evaluated by in situ hybridization and analyzed using digital pathology. To isolate the compartment specific contribution of miR-126, tumor and adjacent tumor stroma were considered separately. In univariate analyses, high expression of miR-126 in tumor and stroma was related to increased disease-specific survival (p<0.001 and p=0.005, respectively). In multivariate analyses, high miR-126 expression in tumor remained a significant independent predictor of improved disease-specific survival (HR=0.42, CI 0.23-0.75, p=0.004). Within different TNM-stages there was a tendency towards the same results, but with statistically significant results in stage II only (p=0.007). High expression of miR-126 is an independent positive prognostic factor in stage I-III colon cancer. This finding may be used to identify patients in need of adjuvant chemotherapy.
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