期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 85, 期 4, 页码 790-794出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2016.01.006
关键词
Multiparametric magnetic resonance imaging; Diffusion weighted imaging; Intravoxel incoherent motion; Prostate cancer; Peripheral zone; Gleason score
Purpose: To evaluate the potential added value of the intravoxel incoherent motion model to conventional multiparametric magnetic resonance protocol in order to differentiate between healthy and neoplastic prostate tissue in the peripheral zone. Material and methods: Mono-exponential and bi-exponential fits were used to calculate ADC and IVIM parameters in 53 patients with peripheral zone biopsy proved tumor. Inferential statistics analysis was performed on T2, ADC and IVIM parameters (D, D*, I) comparing healthy and neoplastic tissues. Linear discriminant analysis was performed for the conventional parameters (T2 and ADC), the IVIM parameters (molecular diffusion coefficient (D), perfusion-related diffusion coefficient (D*), and perfusion fraction (f) and the combined T2-weighted imaging/DWI and IVIM parameters (T2, ADC, D, D* and f). A correlation with Gleason scores was achieved. Results: The values of T2, ADC and D were significantly lower in cancerous tissues (2749.82 +/- 1324.67 ms, 0.76 +/- 0.27 x 10(-3) mm(2)/s and 0.99 +/- 0.38 x 10(-3) mm(2)/s respectively) compared to those found in the healthy tissues (3750.70 +/- 1735.37 ms, 1.39 +/- 0.48 x 10(-3) mm(2)/s and 1.77 +/- 0.36 x 10(-3) mm(2)/s respectively); D* parameter was significantly increased in neoplastic compared to healthy tissue (15.56 +/- 12.91 x 10(-3) mm(2)/s and 10.25 +/- 10.52 x 10(-3) mm(2)/s respectively). The specificity, sensitivity and accuracy of the T2-weighted imaging/DWI and IVIM parameters were 100, 96 and 98%, respectively, compare to 88, 92 and 90% and 96, 92 and 94 for T2-weighted imaging/ADC and IVIM alone. Conclusions: IVIM parameters increase the specificity and sensitivity in the evaluation of peripheral zone prostate cancer. A statistical difference between low grade tumors and high grade tumors has been demostrated in that ADC, D and D* dataset; in particular, D has been found to have the highest significativity. (c) 2016 Elsevier Ireland Ltd. All rights reserved.
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