Copper/reduced graphene oxide film modified electrode for non-enzymatic glucose sensing application

Numerous studies suggest that modification with functional nanomaterials can enhance the electrode electrocatalytic activity, sensitivity, and selectivity of the electrochemical sensors. Here, a highly sensitive and cost-effective disposable non-enzymatic glucose sensor based on copper(II)/reduced graphene oxide modified screen-printed carbon electrode is demonstrated. Facile fabrication of the developed sensing electrodes is carried out by the adsorption of copper(II) onto graphene oxide modified electrode, then following the electrochemical reduction. The proposed sensor illustrates good electrocatalytic activity toward glucose oxidation with a wide linear detection range from 0.10 mM to 12.5 mM, low detection limit of 65 mu M, and high sensitivity of 172 mu A mM(-1) cm(-2) along with satisfactory anti-interference ability, reproducibility, stability, and the acceptable recoveries for the detection of glucose in a human serum sample (95.6-106.4%). The copper(II)/reduced graphene oxide based sensor with the superior performances is a great potential for the quantitation of glucose in real samples.

Automated summary

The sensor modified with copper(II)/reduced graphene oxide shows enhanced electrocatalytic activity for glucose oxidation, with a wide linear detection range, low detection limit, and high sensitivity. It also exhibits satisfactory anti-interference ability, reproducibility, stability, and acceptable recoveries in glucose detection in human serum samples.