期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41598-021-86854-3
关键词
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资金
- JSPS (Japan Society for the Promotion of Science) [15H01972, 15H04781, 15H05059, 15K03417, 15K03982, 15K16181, 15K17232, 15K18174, 15K19241, 15K21266, 15KT0007, 15KT0097, 16H05556, 16K09122, 16K00913, 16K02025, 16K12964, 16K13443, 16K16295, 16K16595, 16K16633, 16K17256, 16K17281, 16K19247, 16K19267, 16K21461, 16K21465, 16KT0014, 17K04305, 17K34567, 17K04306, 25253052, 25713027, 26285138, 26460828, 26780328, 18H03018, 18H04071, 18H03047, 18H00953, 18H00955, 18KK0057, 19H03901, 19H03915, 19H03860, 19K04785, 19K10641, 19K11657, 19K19818, 19K19455, 19K24060, 19K20909, 20H00557]
- Health Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare, Japan [18H04071, H26-Choju-Ippan-006, H27-Ninchisyou-Ippan-001, H28-Choju-Ippan-002, H28-Ninchisyou-Ippan-002, H29-Chikyukibo-Ippan-001, H30-Jyunkankinado-Ippan-004, 19FA1012, 19FA2001]
- Research and Development Grants for Longevity Science from Japan Agency for Medical Research and development (AMED) [JP17dk0110027, JP18dk0110027, JP18ls0110002, JP18le0110009, JP20dk0110034, JP20dk0110037]
- Research Funding for Longevity Sciences from National Center for Geriatrics and Gerontology [24-17, 24-23, 29-42, 30-30, 30-22, 20-19]
- Open Innovation Platform with Enterprises, Research Institute and Academia(OPERA) from the Japan Science and Technology (JST) [JPMJOP1831]
- Japan Foundation For Aging And Health [J09KF00804]
- Innovative Research Program on Suicide Countermeasures [1-4]
- Sasakawa Sports Foundation
- Japan Health Promotion & Fitness Foundation
- Chiba Foundation for Health Promotion & Disease Prevention
- 8020 Research Grant from the 8020 Promotion Foundation [19-2-06]
- Niimi University [1915010]
- Meiji Yasuda Life Foundation of Health and Welfare
- Grants-in-Aid for Scientific Research [19K19455, 19K24060, 19K11657, 19H03915, 16K19247] Funding Source: KAKEN
Frailty was significantly associated with both occurrence of and hospitalization due to pneumonia in older adults. Factors such as instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were also related to pneumonia occurrence and hospitalization.
Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associated with susceptibility to and severity of pneumonia in functionally-independent community-dwelling older adults. In this study, we examined whether frailty increased the susceptibility to pneumonia and hospitalization in older adults. We used cross-sectional data from the Japan Gerontological Evaluation Study; the data was collected by using mail-based, self-reported questionnaires from 177,991 functionally-independent community-dwelling older adults aged >= 65 years. Our results showed that frailty was significantly associated with both occurrence of and hospitalization due to pneumonia after adjustments with covariates; (Preference ratio {PR} 1.92, 95% confidence interval {95% CI} [1.66-2.22] and PR 1.80, 95% CI [1.42-2.28], respectively, p<0.001 for the both). Pre-frailty was associated only with the occurrence of pneumonia. Besides, the instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were associated with either or both occurrence of and hospitalization due to pneumonia. Our results suggest that frailty influenced the susceptibility to and severity of pneumonia in older adults.
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