4.7 Article

Involvement of cancer-derived EMT cells in the accumulation of 18F-fluorodeoxyglucose in the hypoxic cancer microenvironment

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SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -

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NATURE RESEARCH
DOI: 10.1038/s41598-021-88414-1

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  1. JSPS KAKENHI [JP25460399, JP17K18774, JP18H02724, JP19H05462]

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The study reveals that cancer cells undergoing epithelial-mesenchymal transition in hypoxic regions show the highest accumulation of F-18-FDG, suggesting that these regions are a major contributor to increased glucose metabolism.
A high rate of glycolysis, one of the most common features of cancer, is used in positron emission tomography (PET) imaging to visualize tumor tissues using F-18-fluorodeoxyglucose (F-18-FDG). Heterogeneous intratumoral distribution of F-18-FDG in tissues has been established in some types of cancer, and the maximum standardized uptake value (SUVmax) has been correlated with poor prognosis. However, the phenotype of cells that show high F-18-FDG accumulation in tumors remains unknown. Here, we combined quantitative micro-autoradiography with fluorescence immunohistochemistry to simultaneously visualize F-18-FDG distribution, the expression of multiple proteins, and hypoxic regions in the cancer microenvironment of a human A431 xenograft tumor in C.B-17/Icr-scid/scid mice. We found that the highest F-18-FDG accumulation was in cancer-derived cells undergoing epithelial-mesenchymal transition (EMT) in hypoxic regions, implicating these regions as a major contributor to increased glucose metabolism, as measured by F-18-FDG-PET.

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