期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41598-021-85960-6
关键词
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资金
- AECC-Spanish Association Against Cancer [PROYE16074BORR]
- Health Department, Basque Government [2019222027, 2020333024]
- Jesus de Gangoiti Barrera Foundation [FJGB18/002, FJGB19/002]
- Department of Education, Basque Government [PRE_ 2020_2_0007]
- Instituto de Salud Carlos III-Contratos Sara Borrell 2017 [CD17/00128]
- European Social Fund (ESF)-The ESF invests in your future
NK cells acquire memory-like properties following stimulation with IL-12, IL-15 and IL-18, and these cytokine-induced memory-like NK cells have shown promising potential in cancer immunotherapy. NK cells modulate their metabolism in response to cytokine-stimulation, with a link between metabolism and cellular functions.
Natural Killer (NK) cells acquire memory-like properties following a brief stimulation with IL-12, IL-15 and IL-18. These IL-12/15/18-preactivated NK cells, also known as cytokine-induced memory-like (CIML) NK cells, have been revealed as a powerful tool in cancer immunotherapy due to their persistence in the host and their increased effector functions. Several studies have shown that NK cells modulate their metabolism in response to cytokine-stimulation and other stimuli, suggesting that there is a link between metabolism and cellular functions. In this paper, we have analyzed metabolic changes associated to IL-12/15/18-stimulation and the relevance of glycolytic pathway for NK cell effector functions. We have found CIML NK cells are able to retain a metabolic profile shifted towards glycolysis seven days after cytokine withdrawal. Furthermore, we found that treatment with 2-DG differently affects distinct NK cell effector functions and is stimuli-dependent. These findings may have implications in the design of NK cell-based cancer immunotherapies.
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